Application of flowmeter and depth-dependent water quality data for improved production well construction.

Ground water production wells commonly are designed to maximize well yield and, therefore, may be screened over several water-bearing zones. These water-bearing zones usually are identified, and their hydrogeologic characteristics and water quality are inferred, on the basis of indirect data such as geologic and geophysical logs. Production well designs based on these data may result in wells that are drilled deeper than necessary and are screened through zones having low permeability or poor-quality ground water. In this study, we examined the application of flowmeter logging and depth-dependent water quality samples for the improved design of production wells in a complex hydrogeologic setting. As a demonstration of these techniques, a flowmeter log and depth-dependent water quality data were collected from a long-screened production well within a multilayered coastal aquifer system in the Santa Clara-Calleguas Basin, Ventura County, California. Results showed that the well yields most of its water from four zones that constitute 58% of the screened interval. The importance of these zones to well yield was not readily discernible from indirect geologic or geophysical data. The flowmeter logs and downhole water quality data also show that small quantities of poor-quality water could degrade the overall quality of water from the well. The data obtained from one well can be applied to other proposed wells in the same hydrologic basin. The application of flowmeter and depth-dependent water quality data to well design can reduce installation costs and improve the quantity and quality of water produced from wells in complex multiple-aquifer systems.

Evidence that guanylate cyclase is involved in modulating the resting tension and neurally-induced contraction of the guinea pig tracheal muscle.

Electrical field stimulation of guinea-pig tracheal muscle strips produced a frequency-dependent biphasic response consisting of an initial cholinergic contraction followed by relaxation. Both phases of the response were of neural origin. In the presence of methylene blue, a guanylate cyclase inhibitor, the resting tension and the contraction were increased, but the accompanying relaxation was inhibited. However, in the presence of sodium nitroprusside, a guanylate cyclase activator, the resting tension was reduced and the contraction was inhibited, but the relaxation was prolonged and increased. Similarly, in the presence of either 3-isobutyl-1-methylxanthine, which promotes cyclic guanosine monophosphate (cGMP) accumulation, or 8-bromo-cGMP, an analogue of cGMP, the resting tension was reduced and the contraction was inhibited but the relaxation was prolonged and increased. From these results, it is concluded that guanylate cyclase is involved in modulating the resting tension and the neurally-induced contraction of guinea-pig tracheal muscle.

Evidence that guanylate cyclase is involved in modulating the resting tension and neurally induced contraction of the guinea pig tracheal muscle

Electrical field stimulation of guinea-pig tracheal muscle strips produced a frequency-dependent biphasic response consisting of an initial cholinergic contraction followed by relaxation. Both phases of the response were of neural origin. In the presence of methylene blue, a guanylate cyclase inhibitor, the resting tension and the contraction were increased, but the accompanying relaxation was inhibited. However, in the presence of sodium nitroprusside, guanylate cyclase activator, the resting tension was reduced and the contraction was inhibited, but the relaxation was prolonged and increased. Similarly, in the presence of either 3-isobutyl-lmethylxanthine, which promotes cyclic guanosine monophospate (cGMP) accumulation, or 8-bromo-cGMP, an analogue of cGMP, the resting tension was reduced and the contraction was inhibited but the relaxation was prolonged and increased. From these results, it is concluded that guanylate cyclase is involved in modulating the resting tension and the neurally-induced contraction of guinea-pig tracheal muscle(AU)

Evidence that guanylate cyclase is involved in modulating the resting tension and neurally induced contraction of the guinea pig tracheal muscle

Electrical field stimulation of guinea-pig tracheal muscle strips produced a frequency-dependent biphasic response consisting of an initial cholinergic contraction followed by relaxation. Both phases of the response were of neural origin. In the presence of methylene blue, a guanylate cyclase inhibitor, the resting tension and the contraction were increased, but the accompanying relaxation was inhibited. However, in the presence of sodium nitroprusside, guanylate cyclase activator, the resting tension was reduced and the contraction was inhibited, but the relaxation was prolonged and increased. Similarly, in the presence of either 3-isobutyl-lmethylxanthine, which promotes cyclic guanosine monophospate (cGMP) accumulation, or 8-bromo-cGMP, an analogue of cGMP, the resting tension was reduced and the contraction was inhibited but the relaxation was prolonged and increased. From these results, it is concluded that guanylate cyclase is involved in modulating the resting tension and the neurally-induced contraction of guinea-pig tracheal muscle